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WHO Classification of Tumours
WHO Classification of Tumours of the Digestive System
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Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010





C22 - Liver and intrahepatic bile ducts:
 
The number attached to each tumour is the ICD-O morphology code of the International Classification of Diseases for Oncology (ICD-O) [1] and the Systematized Nomenclature of Medicine (http://snomed.org).
/0 benign tumours
/1 unspecified, borderline or uncertain behaviour
/2 in situ carcinomas
/3 malignant tumours.

1. Fritz A, Percy C, Jack A, Shanmuragatnam K, Sobin LH, Parkin DM, Whelan S (Eds) International Classification of Diseases for Oncology. World Health Organization: Geneva 2000





Epithelial tumors
    Non-neoplastic lesion
         Focal nodular hyperplasia (FNH)

    Benign
        8170/0 Hepatocellular adenoma

    Malignant
        8170/3 Hepatocellular carcinoma (HCC), NOS
        8171/3 Hepatocellular carcinoma, fibrolamellar
        8970/3 Hepatoblastoma
        8020/3 Undifferentiated carcinoma

Epithelial tumors: biliary
    Benign
        8160/0 Bile duct adenoma
        8202/0 Microcystic adenoma
        9013/0 Biliary adenofibroma

    Premalignant lesions
        8148/2 Biliary intraepithelial neoplasia, grade 3
        8503/0 Intraductal papillary neoplasm (IPN) with low- or intermediate grade intraepithelial neoplasia
        8503/2 Intraductal papillary neoplasm (IPN) with high-grade intraepithelial neoplasia
        8470/0 Mucinous cystic neoplasm (MCN) with low- or intermediate-grade dysplasia
        8470/2 Mucinous cystic neoplasm (MCN) with high-grade dysplasia

    Malignant
        8160/3 Intrahepatic cholangiocarcinoma
        8503/3 Intraductal papillary neoplasm (IPN) with an associated invasive carcinoma
        8470/3 Mucinous cystic neoplasm (MCN) with an associated invasive carcinoma

Malignancies of mixed or uncertain origin
    8975/1 Calcifying nested epithelial stromal tumor
    8980/3 Carcinosarcoma, NOS
    8180/3 Combined hepatocellular carcinoma and cholangiocarcinoma
    8963/3 Malignant rhabdoid tumor

Mesenchymal tumors
    Non-neoplastic lesions
         Mesenchymal hamartoma
         Inflammatory pseudotumour

    Benign
        8860/0 Angiomyolipoma
        9121/0 Cavernous hemangioma
        9131/0 Capillary hemangioma
        9170/0 Lymphangioma, NOS
        8815/0 Solitary fibrous tumor

    Malignant
        9120/3 Angiosarcoma
        8991/3 Embryonal sarcoma
        9133/1 Epithelioid hemangioendothelioma, NOS
        9140/3 Kaposi sarcoma
        8890/3 Leiomyosarcoma, NOS
        8900/3 Rhabdomyosarcoma, NOS
        9040/3 Synovial sarcoma, NOS

Germ cell tumors
    9080/1 Teratoma, NOS
    9071/3 Yolk sac tumor

Lymphomas
    9680/3 Diffuse large B-cell lymphoma (DLBCL), NOS
    9716/3 Hepatosplenic T-cell lymphoma

Secondary tumours
    Secondary tumours of the liver and intrahepatic bile ducts