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WHO Classification of Tumours
Lymphomas associated with HIV infection
Tumours of haematopoietic and lymphoid tissues


Definition

Lymphomas that develop in HIV-positive patients are predominantly aggressive B-cell lymphomas. In a proportion of cases they are considered acquired ­immunodeficiency syndrome (AIDS)-defining conditions and are the initial manifestation of AIDS. These disorders are heterogeneous and include lymphomas usually diagnosed in immunocompetent patients, as well as those seen much more often in the setting of HIV ­infection. The most common HIV-associated lymphomas include: Burkitt lymphoma (BL), diffuse large B-cell lymphoma (DLBCL) (often involving the central nervous system), primary effusion lymphoma (PEL), and plasmablastic lymphoma . Hodgkin lymphoma (HL) is also increased in the setting of HIV.