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WHO Classification of Tumours
Other iatrogenic immunodeficiency-associated lymphoproliferative disorders
Tumours of haematopoietic and lymphoid tissues


Definition

The other iatrogenic lymphoproliferative disorders (LPD) are lymphoid proliferations or lymphomas that arise in patients treated with immunosuppressive drugs for autoimmune diseases or conditions other than in the allograft/autograft transplant setting. They comprise a spectrum ranging from polymorphic proliferations resembling polymorphic post-transplant lymphoproliferative disorders (PTLD) to cases that fulfill the criteria for diffuse large B-cell lymphoma (DLBCL) or other B-cell lymphomas, peripheral T/NK-cell lymphoma, or classical Hodgkin lymphoma (CHL). Iatrogenically-related lymphomas supervening on haematological malignancies are not covered here
Click to access Pubmed
Abruzzo LV, Rosales CM, Medeiros LJ, Vega F, Luthra R, Manning JT, Keating MJ, Jones D (2002)
Epstein-Barr virus-positive B-cell lymphoproliferative disorders arising in immunodeficient patients previously treated with fludarabine for low-grade B-cell neoplasms.
Am J Surg Pathol 26: 630-6



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