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WHO Classification of Tumours
Indeterminate dendritic cell tumour
Tumours of haematopoietic and lymphoid tissues


Definition

Indeterminate dendritic cell tumour, also known as indeterminate cell histiocytosis, is a neoplastic proliferation of spindled to ovoid cells with phenotypic features similar to those of normal indeterminate cells, the alleged precursor cells of Langerhans cells. These neoplasms are extraordinarily rare
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Andriko JW, Kaldjian EP, Tsokos M, Abbondanzo SL, Jaffe ES (1998)
Reticulum cell neoplasms of lymph nodes: a clinicopathologic study of 11 cases with recognition of a new subtype derived from fibroblastic reticular cells.
Am J Surg Pathol 22: 1048-58




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Berti E, Gianotti R, Alessi E (1988)
Unusual cutaneous histiocytosis expressing an intermediate immunophenotype between Langerhans' cells and dermal macrophages.
Arch Dermatol 124: 1250-3




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Bonetti F, Knowles DM, Chilosi M, Pisa R, Fiaccavento S, Rizzuto N, Zamboni G, Menestrina F, Fiore-Donati L (1985)
A distinctive cutaneous malignant neoplasm expressing the Langerhans cell phenotype. Synchronous occurrence with B-chronic lymphocytic leukemia.
Cancer 55: 2417-25




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Chan WC, Zaatari G (1986)
Lymph node interdigitating reticulum cell sarcoma.
Am J Clin Pathol 85: 739-44




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Kolde G, Bröcker EB (1986)
Multiple skin tumors of indeterminate cells in an adult.
J Am Acad Dermatol 15: 591-7




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Rodriguez J, McLaughlin P, Hagemeister FB, Fayad L, Rodriguez MA, Santiago M, Hess M, Romaguera J, Cabanillas F (1999)
Follicular large cell lymphoma: an aggressive lymphoma that often presents with favorable prognostic features.
Blood 93: 2202-7




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Rosenberg AS, Morgan MB (2001)
Cutaneous indeterminate cell histiocytosis: a new spindle cell variant resembling dendritic cell sarcoma.
J Cutan Pathol 28: 531-7




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Sidoroff A, Zelger B, Steiner H, Smith N (1996)
Indeterminate cell histiocytosis--a clinicopathological entity with features of both X- and non-X histiocytosis.
Br J Dermatol 134: 525-32




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Vasef MA, Zaatari GS, Chan WC, Sun NC, Weiss LM, Brynes RK (1995)
Dendritic cell tumors associated with low-grade B-cell malignancies. Report of three cases.
Am J Clin Pathol 104: 696-701




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Vener C, Soligo D, Berti E, Gianelli U, Servida F, Ceretti E, Caputo R, Passoni E, Lambertenghi Deliliers G (2007)
Indeterminate cell histiocytosis in association with later occurrence of acute myeloblastic leukaemia.
Br J Dermatol 156: 1357-61




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Wood GS, Hu CH, Beckstead JH, Turner RR, Winkelmann RK (1985)
The indeterminate cell proliferative disorder: report of a case manifesting as an unusual cutaneous histiocytosis.
J Dermatol Surg Oncol 11: 1111-9




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Wu CD, Wickert RS, Williamson JE, Sun NC, Brynes RK, Chan WC (1999)
Using fluorescence-based human androgen receptor gene assay to analyze the clonality of microdissected dendritic cell tumors.
Am J Clin Pathol 111: 105-10



. There may be an association with low-grade B-cell lymphoma
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Vasef MA, Zaatari GS, Chan WC, Sun NC, Weiss LM, Brynes RK (1995)
Dendritic cell tumors associated with low-grade B-cell malignancies. Report of three cases.
Am J Clin Pathol 104: 696-701



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