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WHO Classification of Tumours
Paediatric follicular lymphoma
Tumours of haematopoietic and lymphoid tissues


Definition

This variant of follicular lymphoma often involves cervical lymph nodes, other peripheral lymph nodes or Waldeyer ring; however, other extranodal involvement also occurs, with FL of the testis well described
Click to access Pubmed
Finn LS, Viswanatha DS, Belasco JB, Snyder H, Huebner D, Sorbara L, Raffeld M, Jaffe ES, Salhany KE (1999)
Primary follicular lymphoma of the testis in childhood.
Cancer 85: 1626-35




Click to access Pubmed
Lorsbach RB, Shay-Seymore D, Moore J, Banks PM, Hasserjian RP, Sandlund JT, Behm FG (2002)
Clinicopathologic analysis of follicular lymphoma occurring in children.
Blood 99: 1959-64




Click to access Pubmed
Pinto A, Hutchison RE, Grant LH, Trevenen CL, Berard CW (1990)
Follicular lymphomas in pediatric patients.
Mod Pathol 3: 308-13




Click to access Pubmed
Swerdlow SH (2004)
Pediatric follicular lymphomas, marginal zone lymphomas, and marginal zone hyperplasia.
Am J Clin Pathol 122 Suppl: S98-109



. Children with FL typically have early-stage disease
Click to access Pubmed
Finn LS, Viswanatha DS, Belasco JB, Snyder H, Huebner D, Sorbara L, Raffeld M, Jaffe ES, Salhany KE (1999)
Primary follicular lymphoma of the testis in childhood.
Cancer 85: 1626-35




Click to access Pubmed
Lorsbach RB, Shay-Seymore D, Moore J, Banks PM, Hasserjian RP, Sandlund JT, Behm FG (2002)
Clinicopathologic analysis of follicular lymphoma occurring in children.
Blood 99: 1959-64




Click to access Pubmed
Pinto A, Hutchison RE, Grant LH, Trevenen CL, Berard CW (1990)
Follicular lymphomas in pediatric patients.
Mod Pathol 3: 308-13




Click to access Pubmed
Swerdlow SH (2004)
Pediatric follicular lymphomas, marginal zone lymphomas, and marginal zone hyperplasia.
Am J Clin Pathol 122 Suppl: S98-109



. Paediatric follicular lymphomas have many features indistinguishable from those seen in adults, but demonstrate an increased proportion that are localized, lack BCL2 protein expression and t(14;18) and are grade 3
Click to access Pubmed
Lorsbach RB, Shay-Seymore D, Moore J, Banks PM, Hasserjian RP, Sandlund JT, Behm FG (2002)
Clinicopathologic analysis of follicular lymphoma occurring in children.
Blood 99: 1959-64




Click to access Pubmed
Swerdlow SH (2004)
Pediatric follicular lymphomas, marginal zone lymphomas, and marginal zone hyperplasia.
Am J Clin Pathol 122 Suppl: S98-109



. They also tend to have large expansile follicles. Rare cases of florid follicular hyperplasia, particularly in young males, may have clonal populations of CD10+ B-cells detected by flow cytometry and molecular analysis. A diagnosis of lymphoma should not be made in the absence of morphologic features of malignancy
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Kussick SJ, Kalnoski M, Braziel RM, Wood BL (2004)
Prominent clonal B-cell populations identified by flow cytometry in histologically reactive lymphoid proliferations.
Am J Clin Pathol 121: 464-72



. The prognosis of paediatric patients appears to be good, with the majority of reported cases disease free at the time of last follow-up
Click to access Pubmed
Finn LS, Viswanatha DS, Belasco JB, Snyder H, Huebner D, Sorbara L, Raffeld M, Jaffe ES, Salhany KE (1999)
Primary follicular lymphoma of the testis in childhood.
Cancer 85: 1626-35




Click to access Pubmed
Lorsbach RB, Shay-Seymore D, Moore J, Banks PM, Hasserjian RP, Sandlund JT, Behm FG (2002)
Clinicopathologic analysis of follicular lymphoma occurring in children.
Blood 99: 1959-64




Click to access Pubmed
Pinto A, Hutchison RE, Grant LH, Trevenen CL, Berard CW (1990)
Follicular lymphomas in pediatric patients.
Mod Pathol 3: 308-13



. Expression of BCL2 protein in paediatric FL was associated in one report with higher stage at diagnosis and a worse outcome than BCL2 negative cases
Click to access Pubmed
Lorsbach RB, Shay-Seymore D, Moore J, Banks PM, Hasserjian RP, Sandlund JT, Behm FG (2002)
Clinicopathologic analysis of follicular lymphoma occurring in children.
Blood 99: 1959-64



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> Related Topics
Follicular lymphoma
Introduction: Classification of lymphoid neoplasms