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WHO Classification of Tumours
Osteosclerotic myeloma
Tumours of haematopoietic and lymphoid tissues


Definition

Osteosclerotic myeloma is a plasma cell neoplasm characterized by fibrosis and osteosclerotic changes in bone trabeculae, and often with lymph node changes resembling the plasma cell variant of Castleman disease. This disorder is often a component of a rare syndrome that includes polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS)
Click to access Pubmed
Miralles GD, O'Fallon JR, Talley NJ (1992)
Plasma-cell dyscrasia with polyneuropathy. The spectrum of POEMS syndrome.
N Engl J Med 327: 1919-23



. The relationship of this disease to typical plasma cell myeloma is not known.

> Related Topics
Definition: Plasma cell neoplasms
Introduction: Classification of lymphoid neoplasms