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WHO Classification of Tumours
Monoclonal light and heavy chain deposition diseases
Tumours of haematopoietic and lymphoid tissues


Definition

Monoclonal light and heavy chain deposition diseases are plasma cell or rarely lymphoplasmacytic neoplasms that secrete an abnormal light or, less often, heavy chain or both, which deposit in tissues causing organ dysfunction but do not form amyloid ß-pleated sheets, bind Congo red or contain amyloid P-component
Click to access Pubmed
Aucouturier P, Khamlichi AA, Touchard G, Justrabo E, Cogne M, Chauffert B, Martin F, Preud'homme JL (1993)
Brief report: heavy-chain deposition disease.
N Engl J Med 329: 1389-93




Click to access Pubmed
Buxbaum J (1992)
Mechanisms of disease: monoclonal immunoglobulin deposition. Amyloidosis, light chain deposition disease, and light and heavy chain deposition disease.
Hematol Oncol Clin North Am 6: 323-46




Click to access Pubmed
Dimopoulos MA, Kiamouris C, Moulopoulos LA (1999)
Solitary plasmacytoma of bone and extramedullary plasmacytoma.
Hematol Oncol Clin North Am 13: 1249-57




Click to access Pubmed
Herzenberg AM, Lien J, Magil AB (1996)
Monoclonal heavy chain (immunoglobulin G3) deposition disease: report of a case.
Am J Kidney Dis 28: 128-31




Click to access Pubmed
Kambham N, Markowitz GS, Appel GB, Kleiner MJ, Aucouturier P, D'agati VD (1999)
Heavy chain deposition disease: the disease spectrum.
Am J Kidney Dis 33: 954-62




Click to access Pubmed
Preud'homme JL, Aucouturier P, Touchard G, Striker L, Khamlichi AA, Rocca A, Denoroy L, Cogné M (1994)
Monoclonal immunoglobulin deposition disease (Randall type). Relationship with structural abnormalities of immunoglobulin chains.
Kidney Int 46: 965-72




Click to access Pubmed
Randall RE, Williamson WC, Mullinax F, Tung MY, Still WJ (1976)
Manifestations of systemic light chain deposition.
Am J Med 60: 293-9



. These disorders include light chain deposition disease (LCDD)
Click to access Pubmed
Buxbaum J (1992)
Mechanisms of disease: monoclonal immunoglobulin deposition. Amyloidosis, light chain deposition disease, and light and heavy chain deposition disease.
Hematol Oncol Clin North Am 6: 323-46




Click to access Pubmed
Pozzi C, D'Amico M, Fogazzi GB, Curioni S, Ferrario F, Pasquali S, Quattrocchio G, Rollino C, Segagni S, Locatelli F (2003)
Light chain deposition disease with renal involvement: clinical characteristics and prognostic factors.
Am J Kidney Dis 42: 1154-63




Click to access Pubmed
Preud'homme JL, Aucouturier P, Touchard G, Striker L, Khamlichi AA, Rocca A, Denoroy L, Cogné M (1994)
Monoclonal immunoglobulin deposition disease (Randall type). Relationship with structural abnormalities of immunoglobulin chains.
Kidney Int 46: 965-72




Click to access Pubmed
Randall RE, Williamson WC, Mullinax F, Tung MY, Still WJ (1976)
Manifestations of systemic light chain deposition.
Am J Med 60: 293-9



, heavy chain deposition disease (HCDD)
Click to access Pubmed
Aucouturier P, Khamlichi AA, Touchard G, Justrabo E, Cogne M, Chauffert B, Martin F, Preud'homme JL (1993)
Brief report: heavy-chain deposition disease.
N Engl J Med 329: 1389-93




Click to access Pubmed
Herzenberg AM, Lien J, Magil AB (1996)
Monoclonal heavy chain (immunoglobulin G3) deposition disease: report of a case.
Am J Kidney Dis 28: 128-31




Click to access Pubmed
Kambham N, Markowitz GS, Appel GB, Kleiner MJ, Aucouturier P, D'agati VD (1999)
Heavy chain deposition disease: the disease spectrum.
Am J Kidney Dis 33: 954-62



and light and heavy chain deposition disease (LHCDD)
Click to access Pubmed
Buxbaum J (1992)
Mechanisms of disease: monoclonal immunoglobulin deposition. Amyloidosis, light chain deposition disease, and light and heavy chain deposition disease.
Hematol Oncol Clin North Am 6: 323-46




Click to access Pubmed
Dimopoulos MA, Kiamouris C, Moulopoulos LA (1999)
Solitary plasmacytoma of bone and extramedullary plasmacytoma.
Hematol Oncol Clin North Am 13: 1249-57



.

> Related Topics
Immunoglobulin deposition diseases
Primary amyloidosis
Introduction: Classification of lymphoid neoplasms