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WHO Classification of Tumours
Immunoglobulin deposition diseases
Tumours of haematopoietic and lymphoid tissues


Definition

The monoclonal immunoglobulin deposition diseases (MIDD) are closely-related disorders that are characterized by visceral and soft tissue deposition of immuno - globulin, resulting in compromised organ function
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Aucouturier P, Khamlichi AA, Touchard G, Justrabo E, Cogne M, Chauffert B, Martin F, Preud'homme JL (1993)
Brief report: heavy-chain deposition disease.
N Engl J Med 329: 1389-93




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Buxbaum J (1992)
Mechanisms of disease: monoclonal immunoglobulin deposition. Amyloidosis, light chain deposition disease, and light and heavy chain deposition disease.
Hematol Oncol Clin North Am 6: 323-46




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Herzenberg AM, Lien J, Magil AB (1996)
Monoclonal heavy chain (immunoglobulin G3) deposition disease: report of a case.
Am J Kidney Dis 28: 128-31




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Kambham N, Markowitz GS, Appel GB, Kleiner MJ, Aucouturier P, D'agati VD (1999)
Heavy chain deposition disease: the disease spectrum.
Am J Kidney Dis 33: 954-62




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Kyle RA, Gertz MA (1995)
Primary systemic amyloidosis: clinical and laboratory features in 474 cases.
Semin Hematol 32: 45-59




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Preud'homme JL, Aucouturier P, Touchard G, Striker L, Khamlichi AA, Rocca A, Denoroy L, Cogné M (1994)
Monoclonal immunoglobulin deposition disease (Randall type). Relationship with structural abnormalities of immunoglobulin chains.
Kidney Int 46: 965-72




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Randall RE, Williamson WC, Mullinax F, Tung MY, Still WJ (1976)
Manifestations of systemic light chain deposition.
Am J Med 60: 293-9




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Serpell LC, Sunde M, Blake CC (1997)
The molecular basis of amyloidosis.
Cell Mol Life Sci 53: 871-87




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De Wolf-Peeters C, Achten R (2000)
Anaplastic large cell lymphoma: what's in a name?
J Clin Pathol 53: 407-8



. The underlying disorder is typically a plasma cell neoplasm, or rarely a lymphoplasmacytic neoplasm
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Gertz MA, Kyle RA (2003)
Amyloidosis with IgM monoclonal gammopathies.
Semin Oncol 30: 325-8




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Gertz MA, Kyle RA, Noel P (1993)
Primary systemic amyloidosis: a rare complication of immunoglobulin M monoclonal gammopathies and Waldenström's macroglobulinemia.
J Clin Oncol 11: 914-20



; however, the immunoglobulin molecule accumulates in tissue before the development of a large tumour burden. Thus, these patients typically do not have overt myeloma, or lymphoplasmacytic lymphoma at the time of the diagnosis. The MIDD appear to be chemically different manifestations of similar pathological processes, resulting in clinically similar but not identical conditions. There are two major categories of MIDD: primary amyloidosis and light chain deposition disease (LCDD); rarely light and heavy chain deposition disease (LHCDD) and heavy chain deposition disease (HCDD) may be seen.

There are two major types of immunoglobin deposition diseases:

Primary amyloidosis

Monoclonal light and heavy chain deposition diseases


> Related Topics
Definition: Plasma cell neoplasms
Introduction: Classification of lymphoid neoplasms