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WHO Classification of Tumours
Solitary fibrous tumor
Pancreas


Definition

Solitary fibrous tumour (STF) is a slowly growing, localized neoplasm histologically characterized by the presence of round to spindle-shaped cells, hyalinized stroma formation, thin-walled branching blood vessels, and thin bands of collagen. Further common features are myxoid change, areas of fibrosis and interstitial mast cells
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Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002



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STF may arise at any location; roughly 40% are found in subcutaneous tissue. The tumours range in size between 1 and 25 cm and are usually well circumscribed, often partially encapsulated masses. Tumour necrosis and local infiltration may be seen in malignant tumours

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Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002



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SFTs mainly affect adults between 20 and 70 years (median: 50 years). Most cases are benign, but approximately 10-15% follow an aggressive course, long-term follow-up is thus mandatory. SFT metastasizes most frequently to lung, bone and liver

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Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002



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Pancreatic STF
This neoplasm, more commonly seen on the serosal surfaces of the peritoneum, has been described as an intrapancreatic mass

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Lüttges J, Mentzel T, Hübner G, Klöppel G (1999)
Solitary fibrous tumour of the pancreas: a new member of the small group of mesenchymal pancreatic tumours.
Virchows Arch 435: 37-42



. It is composed of bland spindle cells in a variably collagenous to focally myxoid background, and a haemangiopericytoma- like vascular pattern is a usual finding. The neoplastic cells are positive for CD34 and negative for KIT and desmin
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Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



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