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WHO Classification of Tumours
Inflammatory pseudotumour
Liver and intrahepatic bile ducts


Definition

This lesion is defined as a benign, non-neoplastic, non-metastasizing mass composed of fibrous tissue and proliferated myofibroblasts, with a marked inflammatory infiltration, predominantly plasma cells. It has been described under many other names, such as plasma cell granuloma, pseudolymphoma, fibroxanthoma, and histiocytoma, a reflection of the variability of its appearance. In liver lesions, there is a 3 : 1 predominance in males, and mean age at presentation is 37 years (range, 183 years)
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Shek TW, Ng IO, Chan KW (1993)
Inflammatory pseudotumor of the liver. Report of four cases and review of the literature.
Am J Surg Pathol 17: 231-8



. Most patients present with recurrent fever, weight loss and abdominal pain; jaundice develops in a minority. The etiology of this lesion remains unknown, although the myofibroblastic nature of the spindle cells has been well established. Most probably it is a heterogenous lesion, with various infectious and inflammatory causes being proposed
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Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



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