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WHO Classification of Tumours
Gallbladder and extrahepatic biliary tract


Extensive and diffuse infiltration of tissues by ganglioneuroma.

Ganglioneuromatosis of the gallbladder and extrahepatic bile ducts
Diffuse ganglioneuromatosis can involve the gallbladder in patients with multiple endocrine neoplasia type 2B (MEN2B) . The lesions contain Schwann-cell elements admixed with scattered ganglion cells involving the entire wall of the gallbladder

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Carney JA, Sizemore GW, Hayles AB (1978)
Multiple endocrine neoplasia, type 2b.
Pathobiol Annu 8: 105-53

. Diffuse or plexiform neurofibromas can also involve the biliary tract in patients with neurofibromatosis type 1 (NF1)
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Mitchell DI, Char G, McDonald A, Scott P (1995)
Plexiform neurofibroma: a rare cause of obstructive jaundice.
West Indian Med J 44: 146-7

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Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010