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WHO Classification of Tumours
Granular cell tumor, NOS
Colon and rectum


An unusual benign or malignant neoplasm characterized by the presence of neoplastic large polygonal cells with granular, eosinophilic cytoplasm which contains abundant lysosomes. It affects females more often than males and usually presents as a solitary mass. A minority of patients have multiple tumors. Granular cell tumours can arise from many anatomic sites including the posterior pituitary gland, skin, oral cavity, esophagus, stomach, heart, mediastinum, and breast. This tumour was originally thought to originate from muscle cells and was named granular cell myoblastoma. Subsequent studies have suggested a derivation from Schwann cells.

Granular cell tumour of colon and rectum
These tumours usually present as small mucosal nodules incidentally detected at endoscopy. Multiple lesions can be present, and occurrence together with peripheral granular cell tumours is also possible. The neoplastic component consists of large cells with small nuclei and abundant, granular cytoplasm that is positive for PAS and S100 protein

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Melo CR, Melo IS, Schmitt FC, Fagundes R, Amendola D (1993)
Multicentric granular cell tumor of the colon: report of a patient with 52 tumors.
Am J Gastroenterol 88: 1785-7

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Sohn DK, Choi HS, Chang YS, Huh JM, Kim DH, Kim DY, Kim YH, Chang HJ, Jung KH, Jeong SY (2004)
Granular cell tumor of colon: report of a case and review of literature.
World J Gastroenterol 10: 2452-4

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Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010