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WHO Classification of Tumours
Mucinous cystic neoplasm (MCN) with an associated invasive carcinoma
Liver and intrahepatic bile ducts


A mucinous cystic neoplasm (MCN) is a cyst-forming epithelial neoplasm, usually showing no communication with the bile ducts, composed of cuboidal to columnar, variably mucin-producing epithelium, associated with ovarian-type subepithelial stroma. Noninvasive mucinous cystic neoplasms (MCN) are categorized on the basis of the highest degree of cytoarchitectural atypia into MCN with low- or intermediate-grade dysplasia and MCN with high-grade dysplasia . If there is a component of invasive carcinoma, the lesion should be designated as MCN with an associated invasive carcinoma. MCNs occur principally in the liver and occasionally in the extrahepatic biliary system (including the gallbladder). The prognosis for patients with an invasive adenocarcinoma arising in association with MCN is much harder to predict than noninvasive MCNs.
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Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010