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WHO Classification of Tumours
Mucinous cystic neoplasm (MCN) with low- or intermediate-grade dysplasia
Liver and intrahepatic bile ducts


Definition

A benign or low malignant potential cystic epithelial neoplasm composed of cells which contain intracytoplasmic mucin.

In the liver, this cyst-forming epithelial neoplasm usually shows no communication with the bile ducts, composed of cuboidal to columnar, variably mucin-producing epithelium, associated with ovarian-type subepithelial stroma. Noninvasive mucinous cystic neoplasms (MCN) are categorized on the basis of the highest degree of cytoarchitectural atypia into MCN with low or intermediated grade dysplasia, and MCN with high-grade dysplasia . If there is a component of invasive carcinoma, the lesion should be designated as MCN with an associated invasive carcinoma . These neoplasms are rare and occur almost exclusively in women. MCNs occur principally in the liver and occasionally in the extrahepatic biliary system (including the gallbladder)

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Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



. These tumours must be differentiated from intraductal papillary neoplasia (IPN), hepatic microcystic serous cystadenoma of pancreatic type, biliary fibroadenoma, endometriosis and bile duct and peribiliary cysts. The prognosis for patients with a noninvasive biliary MCN is excellent if complete resection is possible
Click for details
Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



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Commentary: Preneoplastic lesions of the digestive system