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WHO Classification of Tumours
Biliary adenofibroma
Liver and intrahepatic bile ducts


Definition

Biliary adenofibroma is characterized by a complex tubulocystic biliary epithelium without mucin production, together with abundant fibroblastic stromal components. There is evidence that this might be related to Von Meyenburg complex on the basis of similar morphological architecture and epithelial expression of D10, but not 1F6
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Varnholt H, Vauthey JN, Dal Cin P, Marsh Rde W, Bhathal PS, Hughes NR, Lauwers GY (2003)
Biliary adenofibroma: a rare neoplasm of bile duct origin with an indolent behavior.
Am J Surg Pathol 27: 693-8



. Because of its size, proliferative activity and immunopositivity for p53, biliary adenofibroma is believed to be a potentially premalignant neoplasm
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Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



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Von Meyenburg complex (biliary microhamartoma) is small, up to several millimetres in diameter. These lesions are usually multiple and are adjacent to a portal tract and, if widespread, may be an indication of fibropolycystic disease of the liver. Within a fibrous or hyalinized stroma, they present as irregular or round ductal structures that appear somewhat dilated and have a flattened or cuboidal epithelium. The lumina contain proteinaceous or bile-stained secretions

Click for details
Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



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