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WHO Classification of Tumours
Papillary hidradenoma
Anus and anal canal


A benign neoplasm arising from the sweat glands. It presents as a slow growing cystic nodular lesion most often in the skin of the vulva and the perianal region. It is characterized by the presence of cystic and large papillary structures. The papillary structures contain connective tissue and are covered by two layers of epithelium. Complete excision is curative.

Anal papillary hidradenoma
This rare tumour arises in the perianal apocrine glands, typically in middle-aged women and only exceedingly rarely in men

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Loane J, Kealy WF, Mulcahy G (1998)
Perianal hidradenoma papilliferum occurring in a male: a case report.
Ir J Med Sci 167: 26-7

. It presents as a circumscribed nodule approximately 1 cm in diameter and may resemble a haemorrhoid. Histologically, it consists of a papillary mass with a cyst-like capsule. The papillae are lined by a double layer of epithelial cells, the outer layer being composed of cells containing mucin. The tumour does not express the eccrine marker IKH4, but it must be remembered that adenocarcinoma metastases are also negative for this marker
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Ishihara M, Mehregan DR, Hashimoto K, Yotsumoto S, Toi Y, Pietruk T, Mehregan AH, Mehregan DA (1998)
Staining of eccrine and apocrine neoplasms and metastatic adenocarcinoma with IKH-4, a monoclonal antibody specific for the eccrine gland.
J Cutan Pathol 25: 100-5

. Convincing examples of anal apocrine adenocarcinoma have not been published
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Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010


Topographic definition of the anal canal, anal margin and perianal region