logo logo
Search: Organ site Search: Tumor / Syndrome
or
WHO Classification of Tumours
Mucinous cystic neoplasm (MCN) with low- or intermediate-grade dysplasia
Gallbladder and extrahepatic biliary tract


Definition

A benign or low malignant potential cystic epithelial neoplasm composed of cells which contain intracytoplasmic mucin.

Mucinous cystic neoplasms (MCNs) of the gallbladder and extrahepatic bile ducts resemble their intrahepatic counterparts. They are seen predominantly in adult females and are usually symptomatic. Some MCNs measure up to 20 cm in diameter and cause obstructive jaundice or cholecystitis-like symptoms. More common in the extrahepatic bile ducts than in the gallbladder, MCNs are multiloculated neoplasms that contain mucinous or serous fluid and are lined by columnar epithelium reminiscent of bile duct or foveolar gastric epithelium

Click to access Pubmed
Devaney K, Goodman ZD, Ishak KG (1994)
Hepatobiliary cystadenoma and cystadenocarcinoma. A light microscopic and immunohistochemical study of 70 patients.
Am J Surg Pathol 18: 1078-91



. Neuroendocrine cells are occasionally present. By definition, the cellular subepithelial stroma resembles ovarian stroma and is immunoreactive for estrogen and progesterone receptors. The stroma is also variably fibrotic. Invasive carcinomas that arise in association with MCNs should be designated MCN with an associated invasive carcinoma
Click to access Pubmed
Devaney K, Goodman ZD, Ishak KG (1994)
Hepatobiliary cystadenoma and cystadenocarcinoma. A light microscopic and immunohistochemical study of 70 patients.
Am J Surg Pathol 18: 1078-91



and clearly described in terms of grade and extent; staging is only required for the invasive component
Click for details
Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



.

For more details please see MCNs of the liver and intrahepatic bile ducts
http://www.pubcan.org/cancer/5872/mucinous-cystic-neoplasm-with-low--or-intermediate-grade-intraepithelial-neoplasia/definition

Commentary: Preneoplastic lesions of the digestive system