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WHO Classification of Tumours
Acinar cell cystadenoma
Pancreas


Definition

Acinar cell cystadenoma is a benign cystic epithelial lesion lined by cells with morphological resemblance to acinar cells and with evidence of pancreatic exocrine enzyme production. This is a rare tumour. Cases are divided into (1) clinically recognized macroscopic lesions and (2) incidental microscopic lesions. Acinar cell cystadenomas produce variably sized cysts. Recognition of acinar differentiation by immunohistochemistry is very helpful for definitive diagnosis. All acinar cell cystadenomas reported to date have been clinically benign, and there is no evidence of malignant transformation or association with acinar cell carcinoma
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Albores-Saavedra J (2002)
Acinar cystadenoma of the pancreas: a previously undescribed tumor.
Ann Diagn Pathol 6: 113-5




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Chatelain D, Paye F, Mourra N, Scoazec JY, Baudrimont M, Parc R, Flejou JF (2002)
Unilocular acinar cell cystadenoma of the pancreas an unusual acinar cell tumor.
Am J Clin Pathol 118: 211-4




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Zamboni G, Terris B, Scarpa A, Kosmahl M, Capelli P, Klimstra DS, Lam PW, Klöppel G (2002)
Acinar cell cystadenoma of the pancreas: a new entity?
Am J Surg Pathol 26: 698-704



. In fact, some authorities have questioned the neoplastic nature of acinar cell cystadenoma, especially of the incidental microscopic examples.