logo logo
Search: Organ site Search: Tumor / Syndrome
or
WHO Classification of Tumours
B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma
Colon and rectum


Definition

B-cell lymphomas with features intermediate between diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL) are aggressive lymphomas that have morphological and genetic features of both DLBCL and BL. The diagnosis of this type of unclassifiable B-cell lymphoma should not be made in cases of morphologically typical DLBCL that have a MYC rearrangement, or in otherwise typical BL in which a MYC rearrangement cannot be demonstrated
Click for details
Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (Eds.)
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
4th Edition
International Agency for Research on Cancer: Lyon 2008



.
More than half of the patients present with widespread, often extranodal disease. Unlike BL, there is no preferential localization in the ileocecal region. The bone marrow (BM) and peripheral blood (PB) may be involved as well. Patients present with lymphadenopathy or mass lesions in extranodal sites. Some patients have a leukaemic presentation. Cases are often resistant to chemotherapy

Click for details
Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (Eds.)
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
4th Edition
International Agency for Research on Cancer: Lyon 2008




Click for details
Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



.