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WHO Classification of Tumours
Neuroendocrine carcinoma, NOS


Pancreatic NETs (neuroendocrine tumours) and NECs (neuroendocrine carcinomas) are classified on the basis of criteria similar to those for other neuroendocrine neoplasms of the gastrointestinal tract as below:

A neuroendocrine carcinoma (NEC) is a poorly differentiated, highgrade malignant neoplasm composed of small cells or large to intermediate cells, sometimes with organoid features resembling NET, diffusely expressing the general markers of neuroendocrine differentiation (diffuse expression of synaptophysin; faint or focal staining for chromogranin A), with marked nuclear atypia, multifocal necrosis and a high number of mitoses (> 20 per 10 HPF); high grade (G3) defined according to the proliferation fraction and histology. This definition refers to neoplasms previously classified as small cell carcinoma, large cell (neuro)endocrine carcinoma, or poorly differentiated (neuro)endocrine carcinoma

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Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010


Commentary: Neuroendocrine tumours of the digestive system