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WHO Classification of Tumours
Adenocarcinoma, NOS
Esophagogastric junction


A common carcinoma characterized by the presence of malignant glandular cells. Morphologically, adenocarcinomas are classified according to their growth pattern (e.g., papillary, alveolar) or according to the secreted product (e.g., mucinous, serous).

Adenocarcinomas of the oesophagogastric junction (OGJ) straddle the junction of the oesophagus and stomach. This definition includes many tumours formerly called cancers of the gastric “cardia”. Squamous cell carcinomas that occur at the OGJ are considered to be carcinomas of the distal oesophagus, even if they cross the OGJ

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Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010

Incidence rates of OGJ adenocarcinomas are higher among Caucasians, in men compared with women, and in the middle-aged and elderly

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Keeney S, Bauer TL (2006)
Epidemiology of adenocarcinoma of the esophagogastric junction.
Surg Oncol Clin N Am 15: 687-96

. The incidence of adenocarcinoma of the OGJ appears to be rising in parallel with that of adenocarcinoma of the lower oesophagus
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Brown LM, Devesa SS, Chow WH (2008)
Incidence of adenocarcinoma of the esophagus among white Americans by sex, stage, and age.
J Natl Cancer Inst 100: 1184-7

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Pera M, Manterola C, Vidal O, Grande L (2005)
Epidemiology of esophageal adenocarcinoma.
J Surg Oncol 92: 151-9

. This is due to common risk factors, i.e gastrooesophageal reflux disease (GORD), overweight/obesity and smoking.

Commentary: Oesophagogastric junction