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WHO Classification of Tumours
Large cell neuroendocrine carcinoma
Region of the ampulla of Vater


Definition

A usually aggressive carcinoma composed of large malignant cells which display neuroendocrine characteristics. It is characterized by the presence of high mitotic activity and necrotic changes. Representative examples include lung, breast, cervical, and thymic neuroendocrine carcinomas.

Commentary: Neuroendocrine tumours of the digestive system