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WHO Classification of Tumours
Undifferentiated carcinoma with osteoclast-like cells
Region of the ampulla of Vater


A usually aggressive malignant epithelial neoplasm composed of giant cells resembling osteoclasts and atypical cells that do not display glandular or squamous differentiation.

Undifferentiated carcinoma with osteoclast-like giant cells of the ampulla of Vater
A very rare form of undifferentiated carcinoma that contains numerous multinucleated osteoclast-like giant cells has been documented in the ampulla

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Albores-Saavedra J, Henson DE, and Klimstra DS eds.
Tumors of the Gallbladder, Extrahepatic Bile Ducts, and Ampulla of Vater
Armed Forces Institute of Pathology: Washington, DC 2000

. This carcinoma is similar to undifferentiated carcinomas with osteoclast-like giant cells reported in the gallbladder, extrahepatic bile ducts and pancreas
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Albores-Saavedra J, Grider DJ, Wu J, Henson DE, Goodman ZD (2006)
Giant cell tumor of the extrahepatic biliary tree: a clinicopathologic study of 4 cases and comparison with anaplastic spindle and giant cell carcinoma with osteoclast-like giant cells.
Am J Surg Pathol 30: 495-500

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Molberg KH, Heffess C, Delgado R, Albores-Saavedra J (1998)
Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas and periampullary region.
Cancer 82: 1279-87

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Westra WH, Sturm P, Drillenburg P, Choti MA, Klimstra DS, Albores-Saavedra J, Montag A, Offerhaus GJ, Hruban RH (1998)
K-ras oncogene mutations in osteoclast-like giant cell tumors of the pancreas and liver: genetic evidence to support origin from the duct epithelium.
Am J Surg Pathol 22: 1247-54

. The giant cells in these tumours are histiocytic and non-neoplastic and label positively for CD68. In contrast, the neoplastic mononuclear cells may be keratin-positive and are often p53-positive
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Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010