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WHO Classification of Tumours
Squamous cell carcinoma, NOS
Region of the ampulla of Vater


A carcinoma arising from squamous epithelial cells, morphologically characterized by the proliferation of atypical, often pleomorphic squamous cells. Squamous cell carcinomas are graded as well, moderately, or poorly differentiated. Well differentiated carcinomas are usually associated with keratin production and the presence of intercellular bridges between adjacent cells. Typical sites of squamous cell carcinomas include the head and neck region, repiratory tract, skin and cervix.

Squamous cell carcinoma of the ampulla of Vater
This exceedingly rare ampullary carcinoma is composed entirely of cells with squamous differentiation. Keratinizing and nonkeratinizing types exist

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Albores-Saavedra J, Henson DE, and Klimstra DS eds.
Tumors of the Gallbladder, Extrahepatic Bile Ducts, and Ampulla of Vater
Armed Forces Institute of Pathology: Washington, DC 2000

. Most ampullary carcinomas with predominant squamous features prove to be adenosquamous carcinomas when extensively sampled and stained for mucin
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Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010