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WHO Classification of Tumours
Hepatoid carcinoma
Region of the ampulla of Vater


Definition

An adenocarcinoma with morphologic characteristics similar to hepatocellular carcinoma arising from an anatomic site other than the liver.

Hepatoid adenocarcinoma of the ampulla of Vater
Fewer than five cases of hepatoid adenocarcinoma of the ampulla have been reported to date

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Gardiner GW, Lajoie G, Keith R (1992)
Hepatoid adenocarcinoma of the papilla of Vater.
Histopathology 20: 541-4




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Sato Y, Tominaga H, Tangoku A, Hamanaka Y, Yamashita Y, Suzuki T (1992)
Alpha-fetoprotein-producing cancer of the ampulla of Vater.
Hepatogastroenterology 39: 566-9



. As its name implies, this neoplasm consists of an adenocarcinoma, usually with an intestinal phenotype, as well as cells closely resembling hepatocytes that grow in sheets or cords. The latter cells are polygonal with abundant eosinophilic cytoplasm are immunoreactive for α-fetoprotein, HepPar1 antibody and polyclonal CEA in a canalicular pattern. Bile pigment has occasionally been identified.