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WHO Classification of Tumours
Clear cell adenocarcinoma, NOS
Region of the ampulla of Vater


Definition

A malignant neoplasm composed of glandular epithelial clear cells. Various architectural patterns may be seen, including papillary, tubulocystic, and solid.

Clear cell adenocarcinoma of the ampulla of Vater
This exceedingly rare form of ampullary carcinoma has a striking resemblance to metastatic renal cell carcinoma

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Albores-Saavedra J, Schwartz AM, Batich K, Henson DE (2009)
Cancers of the ampulla of vater: demographics, morphology, and survival based on 5,625 cases from the SEER program.
J Surg Oncol 100: 598-605




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Venu RP, Rolny P, Geenen JE, Hogan WJ, Komorowski RA, Ferstenberg R (1991)
Ampullary tumor caused by metastatic renal cell carcinoma.
Dig Dis Sci 36: 376-8



. Clear cell carcinoma is composed predominantly or exclusively of polygonal cells with abundant clear cytoplasm, welldefined cytoplasmic membranes and centrally placed hyperchromatic nuclei. The cells are arranged in nests, cords or solid sheets and at least some contain cytoplasmic mucin, a useful feature that can distinguish it from renal cell carcinoma. Because of its rarity, the biological behaviour of clear cell carcinoma of the ampulla is unknown
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Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



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