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WHO Classification of Tumours
Adenocarcinoma, NOS
Region of the ampulla of Vater


A common, malignant tumour characterized by the presence of malignant glandular cells. Morphologically, adenocarcinomas are classified according to the growth pattern (e.g., papillary, alveolar) or according to the secreted product (e.g., mucinous, serous). Representative examples of adenocarcinoma are ductal and lobular breast carcinoma, lung adenocarcinoma, renal cell adenocarcinoma, hepatocellular carcinoma, colon adenocarcinoma, and prostate adenocarcinoma.

Adenocarcinoma of the ampullary of Vater
This is a gland-forming malignant epithelial neoplasm, usually with an intestinal or pancreato-biliary phenotype, which originates in the ampulla of Vater. The ampulla may be affected by carcinomas arising from the duodenal mucosa, the distal common bile duct, or the head of the pancreas, but only those carcinomas either centred on the ampulla, circumferentially surrounding it, or demonstrating complete replacement of the ampulla are regarded as “ampullary carcinoma” for the purposes of classification

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Albores-Saavedra J, Henson DE, and Klimstra DS eds.
Tumors of the Gallbladder, Extrahepatic Bile Ducts, and Ampulla of Vater
Armed Forces Institute of Pathology: Washington, DC 2000

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Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL, and Trotti A (eds.)
AJCC Cancer Staging Manual
Springer: New York 2009


> Histological subtypes
Invasive intestinal-type adenocarcinoma
Pancreatobiliary-type adenocarcinoma
Adenosquamous carcinoma
Clear cell adenocarcinoma
Hepatoid adenocarcinoma
Invasive papillary adenocarcinoma
Mucoid adenocarcinoma
Signet ring cell carcinoma
Squamous cell carcinoma
Poorly differentiated carcinoma
Carcinoma with osteoclast-like giant cells