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WHO Classification of Tumours
Flat intraepithelial neoplasia (dyplasia), high grade
Region of the ampulla of Vater


Flat intraepithelial neoplasia (dysplasia) is a grossly subtle, non-exophytic preinvasive lesion composed of cytologically atypical cells arranged along the native ampullary epithelium. Flat intraepithelial neoplasia (dysplasia) is rarely encountered in the absence of invasive carcinoma
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Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010


Commentary: Preneoplastic lesions of the digestive system