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WHO Classification of Tumours
Langerhans cell sarcoma


Langerhans cell sarcoma (LCS) is a rare neoplasm composed of cells with overtly malignant cytologic features and the Langerhans cell phenotype. Adult females are most commonly affected. LCS can present de novo or progress from antecedent Langerhans cell histiocytosis (LCH). Preferential sites of involvement are skin and underlying soft tissue, often with multi-organ invovlvement
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Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (Eds.)
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
4th Edition
International Agency for Research on Cancer: Lyon 2008