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WHO Classification of Tumours
TSH producing adenoma
Pituitary gland


Definition

TSH producing adenoma is a benign pituitary tumour producing thyrotropin (TSH), originating from adenohypophysial cells
Click for details
Ronald A. DeLellis, Ricardo V. Lloyd, Philipp U. Heitz, Charis Eng
World Health Organization Classification of Tumours. Pathology and Genetics of Tumors of Endocrine Organs
IARC Press: Lyon 2004



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TSH producing adenomas are rare among the pituitary adenomas (1%)

Click to access Pubmed
Bertholon-Grégoire M, Trouillas J, Guigard MP, Loras B, Tourniaire J (1999)
Mono- and plurihormonal thyrotropic pituitary adenomas: pathological, hormonal and clinical studies in 12 patients.
Eur J Endocrinol 140: 519-27



. These tumours usually secrete excess TSH and present with a goiter and hyperthyroidism (hypermetabolic state, tachycardia, tremor, proximal myopathy, neuropsychiatric abnormalities, etc.). Clinically, these patients do not differ from those with Graves disease, with the exception of absent ophthalmopathy or dermopathy.

Due to delay in diagnosis, the tumours are frequently macroadenomas and tend to be invasive and aggressive. Transsphenoidal surgery can achieve a good long-term outcome in about two thirds of patients with TSH producing adenomas, particularly those with microadenomas. Patients with invasive or unresectable tumours need additional treatment with somatostatin analogues, radiation, and/or antithyroid therapy

Click for details
Ronald A. DeLellis, Ricardo V. Lloyd, Philipp U. Heitz, Charis Eng
World Health Organization Classification of Tumours. Pathology and Genetics of Tumors of Endocrine Organs
IARC Press: Lyon 2004



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