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WHO Classification of Tumours
Glandular intraepithelial neoplasia, low grade
Appendix


Definition

Intraepithelial neoplasia is defined as non-invasive cytological or architectural alterations that may lead to to the development of invasive carcinoma. The traditional term dyplasia refers to the the presence of morphological features of neoplasia
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Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



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The development of adenocarcinoma is a multistep process, progressing from normal glandular epithelium to intraepithelial neoplasia (dysplasia), and eventually to invasive carcinoma

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Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



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Commentary: Preneoplastic lesions of the digestive system