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WHO Classification of Tumours
Glandular intraepithelial neoplasia, low grade
Small intestine


Definition

The incidence of small-intestinal adenocarcinoma is increased in patients with chronic inflammatory conditions affecting the small bowel, such as Crohn disease and coeliac disease
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Green PHR , Stavropoulos SN, Panagi SG, Goldstein SL, Mcmahon DJ, Absan H, Neugut AI (2001)
Characteristics of adult celiac disease in the USA: results of a national survey.
Am J Gastroenterol 96: 126-31




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Jess T, Loftus EV, Velayos FS, Harmsen WS, Zinsmeister AR, Smyrk TC, Schleck CD, Tremaine WJ, Melton LJ, Munkholm P, Sandborn WJ (2006)
Risk of intestinal cancer in inflammatory bowel disease: a population-based study from olmsted county, Minnesota.
Gastroenterology 130: 1039-46




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Mellemkjaer L, Johansen C, Gridley G, Linet MS, Kjaer SK, Olsen JH (2000)
Crohn's disease and cancer risk (Denmark).
Cancer Causes Control 11: 145-50




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Michelassi F, Testa G, Pomidor WJ, Lashner BA, Block GE (1993)
Adenocarcinoma complicating Crohn's disease.
Dis Colon Rectum 36: 654-61




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Rampertab SD, Forde KA, Green PH (2003)
Small bowel neoplasia in coeliac disease.
Gut 52: 1211-4



. In patients with Crohn disease, invasive adenocarcinoma is preceded by intraepithelial neoplasia or dysplasia, which may appear either flat or polypoid endoscopically. In one study, dysplasia was identified adjacent to 75% of Crohn disease-associated small- intestinal adenocarcinomas
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Sigel JE, Petras RE, Lashner BA, Fazio VW, Goldblum JR (1999)
Intestinal adenocarcinoma in Crohn's disease: a report of 30 cases with a focus on coexisting dysplasia.
Am J Surg Pathol 23: 651-5



. Histologically, the dysplasia seen in the small bowel appears similar to inflammatory bowel disease associated colonic dysplasia and is classified as low grade and high grade according to the degree of cellular dysplasia
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Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



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Commentary: Preneoplastic lesions of the digestive system