logo logo
Search: Organ site Search: Tumor / Syndrome
or
WHO Classification of Tumours
Mixed adenoneuroendocrine carcinoma
Anus and anal canal


Definition

Mixed adenoneuroendocrine carcinomas (MANEC) have a phenotype that is morphologically recognizable as both gland-forming epithelial and neuroendocrine, and are defined as carcinomas since both components are malignant and should be graded. A component of squamous cell carcinoma is rare. Arbitrarily, at least 30% of either component should be identified to qualify for this definition. The identification in adenocarcinoma of scattered neuroendocrine cells by immunohistochemistry does not qualify for this definition
Click for details
Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



.

Topographic definition of the anal canal, anal margin and perianal region