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WHO Classification of Tumours
Squamous intraepithelial neoplasia (dysplasia), high grade
Anus and anal canal


Definition

Intraepithelial neoplasia is defined as non-invasive cytological or architectural alterations that may lead to to the development of invasive carcinoma. The traditional term dysplasia refers to the presence of morphological features of neoplasia
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Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



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The development of anal squamous cell carcinoma (SCC) is a multistep process, progressing from normal squamous epithelium to intraepithelial neoplasia (dysplasia), and eventually to invasive carcinoma

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Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



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Anal squamous intraepithelial neoplasia (ASIN) and perianal squamous intraepithelial neoplasia (PSIN) are typically originating from the anal transtional zone and perianal skin respectively. High-grade ASIN and PSIN are associated with a higher risk of progression to invasive carcinoma than low-grade intraepithelial neoplasia. Histological features of intraepitehlial neoplasia include cellular disorganization/ loss of polarity and downward growth of the epithelium. Cytological abnormalities include hyperchromasia, increased nucleus:cytoplasm ratio and mitotic activity.

Commentary: Preneoplastic lesions of the digestive system

Topographic definition of the anal canal, anal margin and perianal region