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WHO Classification of Tumours
Serrated adenocarcinoma
Colon and rectum


Definition

This rare variant has architectural similarity to a sessile serrated polyp with glandular serration that may be accompanied by mucinous, cribriform, lacy and trabecular areas and a low nucleus-to-cytoplasm ratio. These tumours can have MSI-L or MSI-H, BRAF mutations, and CpG island hypermethylation
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Jass JR (2007)
Classification of colorectal cancer based on correlation of clinical, morphological and molecular features.
Histopathology 50: 113-30




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Jass JR, Smith M (1992)
Sialic acid and epithelial differentiation in colorectal polyps and cancer--a morphological, mucin and lectin histochemical study.
Pathology 24: 233-42




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Mäkinen MJ (2007)
Colorectal serrated adenocarcinoma.
Histopathology 50: 131-50




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Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



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