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WHO Classification of Tumours
Micropapillary carcinoma
Colon and rectum


This rare variant has small clusters of tumour cells within stromal spaces mimicking vascular channels and has also been described in breast and bladder cancer. The pattern can be seen as a component of conventional CRC. Immunohistochemistry shows a characteristic MUC1 staining pattern
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Hisamori S, Nagayama S, Kita S, Kawamura J, Yoshizawa A, Sakai Y (2009)
Rapid progression of submucosal invasive micropapillary carcinoma of the colon in progressive systemic sclerosis: report of a case.
Jpn J Clin Oncol 39: 399-405

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Kuroda N, Oonishi K, Ohara M, Hirouchi T, Mizuno K, Hayashi Y, Lee GH (2007)
Invasive micropapillary carcinoma of the colon: an immunohistochemical study.
Med Mol Morphol 40: 226-30

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Sakamoto K, Watanabe M, De La Cruz C, Honda H, Ise H, Mitsui K, Namiki K, Mikami Y, Moriya T, Sasano H (2005)
Primary invasive micropapillary carcinoma of the colon.
Histopathology 47: 479-84

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Trabelsi A, Ali AB, Yacoub-Abid LB, Stita W, Mokni M, Korbi S (2008)
Primary invasive micropapillary carcinoma of the colon: case report and review of the literature.
Pathologica 100: 428-30

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Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010