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WHO Classification of Tumours
Synovial sarcoma, NOS


A malignant mesenchymal neoplasm characterized by the chromosomal translocation t(X;18)(p11;q11). It can occur at any age, but mainly affects young adults, more commonly males. Although any site can be affected, the vast majority of the cases arise in the deep soft tissues of extremities, especially around the knee. Microscopically, synovial sarcoma is classified as monophasic (with a spindle or epithelial cell component) or biphasic (with both spindle and epithelial cell components). Synovial sarcomas can recur or metastasize to the lungs, bones, and lymph nodes
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Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002


Isolated cases of biphasic synovial sarcomas have been reported in the upper oesophagus. These have mostly occurred in children and young adults. Grossly, they formed polypoid intraluminal masses, and were histologically similar to synovial sarcomas in soft tissue with glandular elements that were positive for keratin and epithelial membrane antigen (EMA)

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Billings SD, Meisner LF, Cummings OW, Tejada E (2000)
Synovial sarcoma of the upper digestive tract: a report of two cases with demonstration of the X;18 translocation by fluorescence in situ hybridization.
Mod Pathol 13: 68-76

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Bloch MJ, Iozzo RV, Edmunds LH, Brooks JJ (1987)
Polypoid synovial sarcoma of the esophagus.
Gastroenterology 92: 229-33