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WHO Classification of Tumours
Glandular intraepithelial neoplasia, low grade
Esophagus


Definition

Intraepithelial neoplasia is defined as non-invasive cytological or architectural alterations that may lead to to the development of invasive carcinoma. The traditional term dyplasia refers to the the presence of morphological features of neoplasia
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Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



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The development of oesophageal adenoarcinoma is a multistep process, progressing from normal glandular epithelium to intraepithelial neoplasia (dysplasia), and eventually to invasive carcinoma

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Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



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Low-grade intraepithelial neoplasia (dysplasia) is characterized by crypts with relatively preserved architecture, or only minimal distortion, containing cells with atypical pencilshaped nuclei limited to the basal portion of the cell cytoplasm. The nuclei are elongated, enlarged, crowded, hyperchromatic,
show an irregular contour, a dense chromatin pattern either with or without multiple inconspicuous nucleoli, mild pleomorphism and mild loss of polarity, mucin depletion and increased mitoses

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Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



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> Barrett oesophagus is is the most important precursor lesion for oesophageal adenocarcinoma.
For details see: Glandular intraepithelial neoplasia (dysplasia), high grade


Commentary: Preneoplastic lesions of the digestive system