logo logo
Search: Organ site Search: Tumor / Syndrome
or
WHO Classification of Tumours
Glandular intraepithelial neoplasia, high grade
Stomach


Definition

Intraepithelial neoplasia is defined as non-invasive cytological or architectural alterations that may lead to to the development of invasive carcinoma. The traditional term dyplasia refers to the the presence of morphological features of neoplasia
Click for details
Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



.

High-grade intraepithelial neoplasia (dysplasia) is histologically characterized by neoplastic cells that are usually cuboidal, rather than columnar, with a high nucleus to cytoplasm ratio, prominent amphophilic nucleoli, more pronounced architectural disarray and brisk mitotic activity

Click for details
Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



. The nuclei often extend into the luminal aspect of the cell, and nuclear polarity is usually lost. For polypoid lesions, the term “high-grade adenoma” has been used
Click to access Pubmed
Schlemper RJ, Riddell RH, Kato Y, Borchard F, Cooper HS, Dawsey SM, Dixon MF, Fenoglio-Preiser CM, Fléjou JF, Geboes K, Hattori T, Hirota T, Itabashi M, Iwafuchi M, Iwashita A, Kim YI, Kirchner T, Klimpfinger M, Koike M, Lauwers GY, Lewin KJ, Oberhuber G, Offner F, Price AB, Rubio CA, Shimizu M, Shimoda T, Sipponen P, Solcia E, Stolte M, Watanabe H, Yamabe H (2000)
The Vienna classification of gastrointestinal epithelial neoplasia.
Gut 47: 251-5



.

Commentary: Preneoplastic lesions of the digestive system