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WHO Classification of Tumours
Poorly cohesive carcinoma, including signet ring cell carcinoma and other variants
Stomach


Definition

Poorly cohesive carcinomas are composed of neoplastic cells that are isolated or
arranged in small aggregates. These encompass:

> Signet-ring cell carcinoma
This type is defined as a tumour composed predominantly or exclusively of
signet-ring cells, characterized by a central optically clear, globoid droplet of cytoplasmic mucin with an eccentrically placed nucleus. In some cases, signet-ring cells may be restricted to the mucosa in combination with other variants of poorly cohesive cells within the deeper levels of the gastric wall

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Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



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> Other cellular variants of poorly cohesive carcinoma
These include tumours composed of neoplastic cells resembling histiocytes or
lymphocytes; others have deeply eosinophilic cytoplasm; some poorly cohesive
cells may show irregular, bizarre nuclei. A mixture of the different cell types can be present, including few signet-ring cells

Click for details
Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



.