Enterochromaffin cell (EC), serotonin-producing neuroendocrine tumour (NET)
Most neuroendocrine neoplasms of the stomach are NETs – well-differentiated, nonfunctioning enterochromaffin-like (ECL) cell carcinoids (ECL cell NETs) that mainly produce histamine and histidine decarboxylase. However, minor cell subpopulations expressing serotonin, ghrelin, gastrin, somatostatin, pancreatic polypeptide (PP), or α-human chorionic gonadotrophin (α-hCG) have been detected
Papotti M, Cassoni P, Volante M, Deghenghi R, Muccioli G, Ghigo E (2001)
Ghrelin-producing endocrine tumors of the stomach and intestine.
J Clin Endocrinol Metab 86: 5052-9
Rindi G, Luinetti O, Cornaggia M, Capella C, Solcia E (1993)
Three subtypes of gastric argyrophil carcinoid and the gastric neuroendocrine carcinoma: a clinicopathologic study.
Gastroenterology 104: 994-1006
Rindi G, Savio A, Torsello A, Zoli M, Locatelli V, Cocchi D, Paolotti D, Solcia E (2002)
Ghrelin expression in gut endocrine growths.
Histochem Cell Biol 117: 521-5
EC cell, serotonin-producing NETs of the stomach is rare. This tumour may arise in both the corpus–fundus and antrum of the stomach. It is occasionally found in association with a carcinoid syndrome
CHRISTODOULOPOULOS JB, KLOTZ AP (1961)
. Its histopathology is similar to that of the ileal NETs. The tumour cells are argentaffin, intensely argyrophilic and immunoreactive for chromogranin A, synaptophysin and anti-serotonin antibodies. The presence of EC cells is confirmed via electron microscopic detection of characteristic pleomorphic, intensely osmiophilic granules similar to those of normal gastric EC cells
Carcinoid syndrome with primary carcinoid tumor of the stomach.
Gastroenterology 40: 429-40
Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
International Agency for Research on Cancer: Lyon 2010
Commentary: Neuroendocrine tumours of the digestive system