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WHO Classification of Tumours
Enterochromaffin cell (EC), serotonin-producing neuroendocrine tumour (NET)


Most neuroendocrine neoplasms of the stomach are NETs – well-differentiated, nonfunctioning enterochromaffin-like (ECL) cell carcinoids (ECL cell NETs) that mainly produce histamine and histidine decarboxylase. However, minor cell subpopulations expressing serotonin, ghrelin, gastrin, somatostatin, pancreatic polypeptide (PP), or α-human chorionic gonadotrophin (α-hCG) have been detected
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Papotti M, Cassoni P, Volante M, Deghenghi R, Muccioli G, Ghigo E (2001)
Ghrelin-producing endocrine tumors of the stomach and intestine.
J Clin Endocrinol Metab 86: 5052-9

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Rindi G, Luinetti O, Cornaggia M, Capella C, Solcia E (1993)
Three subtypes of gastric argyrophil carcinoid and the gastric neuroendocrine carcinoma: a clinicopathologic study.
Gastroenterology 104: 994-1006

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Rindi G, Savio A, Torsello A, Zoli M, Locatelli V, Cocchi D, Paolotti D, Solcia E (2002)
Ghrelin expression in gut endocrine growths.
Histochem Cell Biol 117: 521-5


EC cell, serotonin-producing NETs of the stomach is rare. This tumour may arise in both the corpus–fundus and antrum of the stomach. It is occasionally found in association with a carcinoid syndrome

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Carcinoid syndrome with primary carcinoid tumor of the stomach.
Gastroenterology 40: 429-40

. Its histopathology is similar to that of the ileal NETs. The tumour cells are argentaffin, intensely argyrophilic and immunoreactive for chromogranin A, synaptophysin and anti-serotonin antibodies. The presence of EC cells is confirmed via electron microscopic detection of characteristic pleomorphic, intensely osmiophilic granules similar to those of normal gastric EC cells
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Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010


Commentary: Neuroendocrine tumours of the digestive system