logo logo
Search: Organ site Search: Tumor / Syndrome
or
WHO Classification of Tumours
Hepatoid carcinoma
Stomach


Definition

An adenocarcinoma with morphologic characteristics similar to hepatocellular carcinoma , arising from an anatomic site other than the liver.

Hepatoid adenocarcinoma of the stomach is composed of large polygonal eosinophilic hepatocyte-like neoplastic cells. α-Fetoprotein (AFP) can be detected in situ, but also in the serum. Bile and periodic acid-Schiff (PAS)- positive and diastase-resistant intracytoplasmic eosinophilic globules can be observed

Click for details
Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



. Other rare AFP-producing carcinomas include well-differentiated papillary or tubular-type adenocarcinoma with clear cytoplasm and yolk-sac tumour-like carcinoma
Click to access Pubmed
Inagawa S, Shimazaki J, Hori M, Yoshimi F, Adachi S, Kawamoto T, Fukao K, Itabashi M (2001)
Hepatoid adenocarcinoma of the stomach.
Gastric Cancer 4: 43-52




Click to access Pubmed
Ishikura H, Kirimoto K, Shamoto M, Miyamoto Y, Yamagiwa H, Itoh T, Aizawa M (1986)
Hepatoid adenocarcinomas of the stomach. An analysis of seven cases.
Cancer 58: 119-26




Click to access Pubmed
Motoyama T, Aizawa K, Watanabe H, Fukase M, Saito K (1993)
alpha-Fetoprotein producing gastric carcinomas: a comparative study of three different subtypes.
Acta Pathol Jpn 43: 654-61




Click to access Pubmed
Nagai E, Ueyama T, Yao T, Tsuneyoshi M (1993)
Hepatoid adenocarcinoma of the stomach. A clinicopathologic and immunohistochemical analysis.
Cancer 72: 1827-35



.