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WHO Classification of Tumours
Hepatoid carcinoma


An adenocarcinoma with morphologic characteristics similar to hepatocellular carcinoma , arising from an anatomic site other than the liver.

Hepatoid adenocarcinoma of the stomach is composed of large polygonal eosinophilic hepatocyte-like neoplastic cells. α-Fetoprotein (AFP) can be detected in situ, but also in the serum. Bile and periodic acid-Schiff (PAS)- positive and diastase-resistant intracytoplasmic eosinophilic globules can be observed

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Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010

. Other rare AFP-producing carcinomas include well-differentiated papillary or tubular-type adenocarcinoma with clear cytoplasm and yolk-sac tumour-like carcinoma
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Inagawa S, Shimazaki J, Hori M, Yoshimi F, Adachi S, Kawamoto T, Fukao K, Itabashi M (2001)
Hepatoid adenocarcinoma of the stomach.
Gastric Cancer 4: 43-52

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Ishikura H, Kirimoto K, Shamoto M, Miyamoto Y, Yamagiwa H, Itoh T, Aizawa M (1986)
Hepatoid adenocarcinomas of the stomach. An analysis of seven cases.
Cancer 58: 119-26

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Motoyama T, Aizawa K, Watanabe H, Fukase M, Saito K (1993)
alpha-Fetoprotein producing gastric carcinomas: a comparative study of three different subtypes.
Acta Pathol Jpn 43: 654-61

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Nagai E, Ueyama T, Yao T, Tsuneyoshi M (1993)
Hepatoid adenocarcinoma of the stomach. A clinicopathologic and immunohistochemical analysis.
Cancer 72: 1827-35