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WHO Classification of Tumours
Medullary carcinoma with lymphoid stroma
Stomach


Definition

This tumour, also reported as lymphoepithelioma-like carcinoma or medullary carcinoma, is characterized by poorly developed tubular structures associated with a prominent lymphoid infiltration of the stroma. These tumours frequently affect the proximal stomach or gastric stump and are more common in males while > 80% are associated with infection with Epstein-Barr virus (EBV)
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Murphy G, Pfeiffer R, Camargo MC, Rabkin CS (2009)
Meta-analysis shows that prevalence of Epstein-Barr virus-positive gastric cancer differs based on sex and anatomic location.
Gastroenterology 137: 824-33



. The role of EBV in carcinogenesis is debated, but occurs at an early stage since EBV can be found in adjacent dysplasia. The prognosis for patients with these tumours is reportedly better than that for patients with typical gastric cancers
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Matsunou H, Konishi F, Hori H, Ikeda T, Sasaki K, Hirose Y, Yamamichi N (1996)
Characteristics of Epstein-Barr virus-associated gastric carcinoma with lymphoid stroma in Japan.
Cancer 77: 1998-2004




Click to access Pubmed
Murphy G, Pfeiffer R, Camargo MC, Rabkin CS (2009)
Meta-analysis shows that prevalence of Epstein-Barr virus-positive gastric cancer differs based on sex and anatomic location.
Gastroenterology 137: 824-33




Click to access Pubmed
Nakamura S, Ueki T, Yao T, Ueyama T, Tsuneyoshi M (1994)
Epstein-Barr virus in gastric carcinoma with lymphoid stroma. Special reference to its detection by the polymerase chain reaction and in situ hybridization in 99 tumors, including a morphologic analysis.
Cancer 73: 2239-49




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Wang HH, Wu MS, Shun CT, Wang HP, Lin CC, Lin JT (1999)
Lymphoepithelioma-like carcinoma of the stomach: a subset of gastric carcinoma with distinct clinicopathological features and high prevalence of Epstein-Barr virus infection.
Hepatogastroenterology 46: 1214-9




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Watanabe H, Enjoji M, Imai T (1976)
Gastric carcinoma with lymphoid stroma. Its morphologic characteristics and prognostic correlations.
Cancer 38: 232-43




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Willems S, Carneiro F, Geboes K (2005)
Gastric carcinoma with osteoclast-like giant cells and lymphoepithelioma-like carcinoma of the stomach: two of a kind?
Histopathology 47: 331-3




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Yamamoto N, Tokunaga M, Uemura Y, Tanaka S, Shirahama H, Nakamura T, Land CE, Sato E (1994)
Epstein-Barr virus and gastric remnant cancer.
Cancer 74: 805-9



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