logo logo
Search: Organ site Search: Tumor / Syndrome
or
WHO Classification of Tumours
Paraganglioma
Adrenal gland


Definition

Extra-adrenal paraganglioma: Carotid body, jugulotympanic, vagal, laryngeal, aortico-pulmonary tumours arising from the paraganglia distributed along the parasympathetic nerves in the head, neck and mediastinum. These tumours are histologically identical and are named by anatomical site of origin
Click for details
Ronald A. DeLellis, Ricardo V. Lloyd, Philipp U. Heitz, Charis Eng
World Health Organization Classification of Tumours. Pathology and Genetics of Tumors of Endocrine Organs
IARC Press: Lyon 2004



.

These neoplasms are rare. Jugulotympanic and carotid body tumours are the two most frequent. A significant increase in the incidence of carotid body paraganglioma has been reported in humans dwelling at high altitude, where a marked female predilection has been reported

Click to access Pubmed
Rodríguez-Cuevas S, López-Garza J, Labastida-Almendaro S (1998)
Carotid body tumors in inhabitants of altitudes higher than 2000 meters above sea level.
Head Neck 20: 374-8



.
It is generally accepted that a paraganglioma is determined to be malignant only when metastases are demonstrated.