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WHO Classification of Tumours


Sebaceoma is a rare, slow-growing, benign adnexal tumour with sebaceous differentiation. The lesion presents as a yellow to orange, solitary papule, mainly on the face and scalp. Sebaceoma may be associated with Muir-Torre syndrome ; in these cases, there are frequently multiple lesions. Histologically, the tumour is characterized by well-circumscribed lobules and cystic spaces. The lobules are composed of small, immature secacous cells with an admixture of randomly scattered mature sebocytes.
Sebaceomas typically affect elderly people, but may occasionally arise in young adults. They show a predilection for women. The tumour does not recur after excision and does not metastasize. Patients with Muir-Torre syndrome have a high risk of internal malignancies

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LeBoit PE, Burg G, Weedon D, Sarasin A (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Skin Tumours
3rd Edition
IARC Press: Lyon 2005