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WHO Classification of Tumours
Pituitary carcinoma, NOS
Pituitary gland


Definition

The term pituitary carcinoma is restricted to a tumour of adenohypophysial cells that exhibits cerebrospinal and/or systemic metastasis.

Because of the highly restrictive definition of pituitary carcinoma, these malignancies are very rare. Pituitary carcinomas affect adults of any age; there is no significant gender bias. More than 75% are endocrinologically functional.

The etiology of pituitary carcinomas is unknown. It remains to be determined whether pituitary carcinomas arise de novo, transform via genetic events from adenomas, or both. It remains to be determined whether pituitary carcinomas arise de novo, transform via genetic events from adenomas, or both

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Ronald A. DeLellis, Ricardo V. Lloyd, Philipp U. Heitz, Charis Eng
World Health Organization Classification of Tumours. Pathology and Genetics of Tumors of Endocrine Organs
IARC Press: Lyon 2004



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In general, patients who develop malignant tumours of the anterior pituitary have a poor prognosis. The number of published cases is insufficient to draw conclusions concerning appropriate therapy. Recent case reports suggest successful ttreatment with temozolomide

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Philippon M, Morange I, Barrie M, Barlier A, Taieb D, Dufour H, Conte-Devolx B, Brue T, Castinetti F (2012)
Long-term control of a MEN1 prolactin secreting pituitary carcinoma after temozolomide treatment.
Ann Endocrinol (Paris) 73: 225-9




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Morokuma H, Ando T, Hayashida T, Horie I, Inoshita N, Murata F, Ueki I, Nakamura K, Imaizumi M, Usa T, Kawakami A (2012)
A case of nonfunctioning pituitary carcinoma that responded to temozolomide treatment.
Case Rep Endocrinol 2012: 645914



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