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WHO Classification of Tumours
Verruca plantaris
Skin


Definition

Verrucas or condyloma are common, benign, contagious epithelial tumours caused by infection with human papillomaviruses (HPV).

Verruca plantaris is a benign epithelial proliferation occurring on the sole of the foot. Plantar warts are sharply defined, thick, hyperkeratotic, rounded lesions, surrounded by a thickened horn .
Plantar warts are most common in children and young adults, most frequent over
pressure points. In children they may spontaneously regress within a few months, but in adults and immunocompromised patients they can persist for years. Regression of palmo-plantar warts is often associated with thrombosis of
superficial vessels, haemorrhage, focal necrosis and a mixed inflammatory cell infiltrate. Rarely chronic lesions are associated with the development of
verrucous carcinoma

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LeBoit PE, Burg G, Weedon D, Sarasin A (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Skin Tumours
3rd Edition
IARC Press: Lyon 2005



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> Superficial warts (mosaic) are ordinary verrucae, typically caused by HPV-2 and HPV-4. Histological features include acanthosis, papillomatosis, hyperkeratosis, vacuolated cells (koilocytes) in the upper Malpighian layer, vertical tiers of parakeratotic cells and clumped keratohyaline granules

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LeBoit PE, Burg G, Weedon D, Sarasin A (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Skin Tumours
3rd Edition
IARC Press: Lyon 2005



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> Deep warts (myrmecia) are typically caused by HPV-1 and HPV-63 and characterized by an endophytic proliferation of rete ridges covered by thickened keratin and prominent eosinophilic intracytoplasmic inclusions

Click for details
LeBoit PE, Burg G, Weedon D, Sarasin A (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Skin Tumours
3rd Edition
IARC Press: Lyon 2005



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