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WHO Classification of Tumours
Arsenical keratosis
Skin


Definition

Arsenical keratosis is a precancerous lesion occurring in patients with past therapeutic, environmental or occupational exposure to to arsenic. Arsenical keratoses begin as yellowish verrucous papules, 4-10 mm in diameter and are typically located on thenar eminences, lateral borders of palms, base or lateral surfaces of fingers, soles, heels and toes. A combination of melanosis and multiple keratoses in non-sunexposed areas in adults is highly suggestive of chronic arsenic exposure
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LeBoit PE, Burg G, Weedon D, Sarasin A (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Skin Tumours
3rd Edition
IARC Press: Lyon 2005



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Histological features include compact hyperkeratosis, acanthosis, papillomatosis, hypertrophic actinic keratosis-like lesions and a pattern resembling seborrhoeic keratosis

Click for details
LeBoit PE, Burg G, Weedon D, Sarasin A (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Skin Tumours
3rd Edition
IARC Press: Lyon 2005



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