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WHO Classification of Tumours
Pseudovascular squamous cell carcinoma


Pseudovascular squamous cell carcinoma is a rare, aggressive variant of squamous cell carcinoma (SCC) , histologically characterized by marked acantholysis, resulting in a pseudovascular pattern similar to angiosarcoma. The internal pseudolumina contain detached tumour cells and amorphous basophilic material. The pseudovascular spaces may also contain erythrocytes
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LeBoit PE, Burg G, Weedon D, Sarasin A (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Skin Tumours
3rd Edition
IARC Press: Lyon 2005

The lesions usually develop on sun-exposed skin of middle-aged or elderly patients. The prognosis is worse than for other variants of SCC, with a mortality rate of up to 50%.