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WHO Classification of Tumours
Nevoid melanoma
Skin


Definition

Naevoid melanoma is an uncommon subtype of malignant melanoma of the skin that closely mimics architectural and cytological features of a benign compound or intraepidermal naevus. It involves the dermis and has the potential for metastasis. Histologically, areas of sheetlike confluent melanocytic proliferation in the dermis are typical; the malignant cells are generally epithelioid.
Most naevoid melanomas are found on the trunk and proximal extremities. The lesions are generally papular, nodular, or verrucous, and laterally sharply demarcated; they often reach 5-10 mm in diameter.
Naevoid melanomas account for approximately 1-2% of all cutaneous melanomas. They occur in all age groups, but most frequently in young to middle-aged adults. Prognostic factors are tumour thickness, mitotic rate, and large cell type. Overall, the prognosis is similar to that of classical malignant melanoma

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LeBoit PE, Burg G, Weedon D, Sarasin A (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Skin Tumours
3rd Edition
IARC Press: Lyon 2005



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